Clinical and Molecular Features of Thiazide-Induced Hyponatremia
نویسندگان
چکیده
منابع مشابه
Thiazide-Induced Hyponatremia
The importance of thiazide-induced hyponatremia (TIH) is reemerging because thiazide diuretic prescription seems to be increasing after the guidelines recommending thiazides as first-line treatment of essential hypertension have been introduced. Thiazide diuretics act by inhibiting reabsorption of Na(+) and Cl(-) from the distal convoluted tubule by blocking the thiazide-sensitive Na(+)/Cl(-) c...
متن کاملClinical and Genetic Factors Associated With Thiazide-Induced Hyponatremia
Thiazide diuretics are associated with an increased risk of hyponatremia. The aim of this study was to investigate possible predictors of thiazide-induced hyponatremia.A total of 48 patients admitted to the ward or to the emergency department due to severe thiazide-induced hyponatremia (Na < 125 mmol/L) were enrolled in our study as the case group. Another 211 hypertensive patients with normal ...
متن کاملIncreased Susceptibility to Thiazide-Induced Hyponatremia
Hyponatremia is a common cause of morbidity in the elderly, and thiazide diuretics are often implicated. Eleven healthy young volunteers, eight healthy old volunteers, and five elderly patients with a history of thiazide-induced hyponatremia were studied to determine susceptibility to thiazide-induced hypoosmolality in age. Each of the healthy subjects ingested a water load (20 mL/kg) after 3 d...
متن کاملPhenotypic and pharmacogenetic evaluation of patients with thiazide-induced hyponatremia
Thiazide diuretics are among the most widely used treatments for hypertension, but thiazide-induced hyponatremia (TIH), a clinically significant adverse effect, is poorly understood. Here, we have studied the phenotypic and genetic characteristics of patients hospitalized with TIH. In a cohort of 109 TIH patients, those with severe TIH displayed an extended phenotype of intravascular volume exp...
متن کاملCorrelation between Hyponatremia and High Risk Clinical and Echocardiographic Features in Patients with Acute Heat Failure
Background and purpose: Heart failure (HF) is characterized by decreased ability of the heart to provide sufficient blood flow or fill with the blood. Hyponatremia is the most commonly seen electrolyte abnormality in patients with heart failure that is associated with increased morbidity and mortality. The aim of this study was to assess the correlation between hyponatremia and high risk clinic...
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ژورنال
عنوان ژورنال: Current Hypertension Reports
سال: 2018
ISSN: 1522-6417,1534-3111
DOI: 10.1007/s11906-018-0826-6